Version 5.4
Bos taurus Protein: POLR2L
Summary
InnateDB Protein IDBP-698213.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR2L
Protein Name DNA-directed RNA polymerases I, II, and III subunit RPABC5
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000041501
InnateDB Gene IDBG-645511 (POLR2L)
Protein Structure
UniProt Annotation
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001054 RNA polymerase I activity
GO:0001055 RNA polymerase II activity
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006383 transcription from RNA polymerase III promoter
Cellular Component
GO:0005634 nucleus
GO:0005665 DNA-directed RNA polymerase II, core complex
GO:0005666 DNA-directed RNA polymerase III complex
GO:0005736 DNA-directed RNA polymerase I complex
Protein Structure and Domains
PDB ID
InterPro IPR000268 DNA-directed RNA polymerase, subunit N/Rpb10
IPR023580 RNA polymerase subunit RPB10
PFAM PF01194
PRINTS
PIRSF PIRSF005653
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q32P78
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 617375
UniGene
RefSeq NP_001107198
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC108227
GenPept AAI08228

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca