InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ANP32A

Summary

InnateDB Protein

IDBP-698224.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANP32A

Protein Name

Acidic leucine-rich nuclear phosphoprotein 32 family member A

Synonyms

ANP32D; HPPCn; LANP; PHAPI;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000016410

InnateDB Gene

IDBG-645519 (ANP32A)

Protein Structure

UniProt Annotation

Function

Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm. Endoplasmic reticulum {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm. Translocates to the cytoplasm during the process of neuritogenesis (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely distributed in the central nervous system, with an abundant expression in the cerebellum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006913	nucleocytoplasmic transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0016363	nuclear matrix
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001611 Leucine-rich repeat
IPR003603 U2A\'/phosphoprotein 32 family A, C-terminal

PFAM

PF00560
PF13504
PF13855

PRINTS

PIRSF

SMART

SM00446

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51122

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

538427

UniGene

Bt.27190

RefSeq

NP_001181948

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

CN437768 DV929633

GenPept