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InnateDB Protein
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IDBP-698232.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GLCE
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Protein Name
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D-glucuronyl C5-epimerase
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000001844
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InnateDB Gene
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IDBG-645524 (GLCE)
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Protein Structure
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| Function |
Converts D-glucuronic acid residues adjacent to N- sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. {ECO:0000269PubMed:11274177}.
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| Subcellular Localization |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
| Accession |
GO Term |
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GO:0016853
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isomerase activity
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GO:0016857
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racemase and epimerase activity, acting on carbohydrates and derivatives
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GO:0047464
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heparosan-N-sulfate-glucuronate 5-epimerase activity
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GO:0050379
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UDP-glucuronate 5'-epimerase activity
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| Biological Process |
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GO:0006024
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glycosaminoglycan biosynthetic process
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GO:0015012
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heparan sulfate proteoglycan biosynthetic process
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GO:0030210
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heparin biosynthetic process
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR010598
D-glucuronyl C5-epimerase
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| PFAM |
PF06662
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
O18756
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
281195
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| UniGene |
Bt.601
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| RefSeq |
NP_776495
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| HUGO |
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AF003927
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| GenPept |
AAB72083
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Version 5.4