Version 5.4
Bos taurus Protein: HRAS
Summary
InnateDB Protein IDBP-698316.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HRAS
Protein Name v-Ha-ras Harvey rat sarcoma viral oncogene homolog
Synonyms H-Ras;
Species Bos taurus
Ensembl Protein ENSBTAP00000055845
InnateDB Gene IDBG-645593 (HRAS)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.
Predicted by orthology
Total 80 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0007050 cell cycle arrest
GO:0007093 mitotic cell cycle checkpoint
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007569 cell aging
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008542 visual learning
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0015031 protein transport
GO:0030036 actin cytoskeleton organization
GO:0030335 positive regulation of cell migration
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0032855 positive regulation of Rac GTPase activity
GO:0034259 negative regulation of Rho GTPase activity
GO:0035022 positive regulation of Rac protein signal transduction
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0045596 negative regulation of cell differentiation
GO:0045740 positive regulation of DNA replication
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051146 striated muscle cell differentiation
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090303 positive regulation of wound healing
GO:0090398 cellular senescence
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900029 positive regulation of ruffle assembly
GO:2000251 positive regulation of actin cytoskeleton reorganization
GO:2000630 positive regulation of miRNA metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00009
PF00071
PF00025
PF08477
PRINTS PR00315
PR00449
PR00328
PIRSF
SMART SM00174
SM00175
SM00173
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q28174
UniProt Splice Variant
Entrez Gene 100298939
UniGene
RefSeq NP_001229275
HUGO HGNC:5173
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02063775 X17363
GenPept CAA35240

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca