Version 5.4
Bos taurus Protein: HEXA
Summary
InnateDB Protein IDBP-698322.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HEXA
Protein Name Beta-hexosaminidase subunit alpha
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017261
InnateDB Gene IDBG-645595 (HEXA)
Protein Structure
UniProt Annotation
Function Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. {ECO:0000250}.
Subcellular Localization Lysosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004563 beta-N-acetylhexosaminidase activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0001501 skeletal system development
GO:0005975 carbohydrate metabolic process
GO:0006689 ganglioside catabolic process
GO:0007040 lysosome organization
GO:0007605 sensory perception of sound
GO:0007626 locomotory behavior
GO:0007628 adult walking behavior
GO:0008152 metabolic process
GO:0019915 lipid storage
GO:0019953 sexual reproduction
GO:0030203 glycosaminoglycan metabolic process
GO:0042552 myelination
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050884 neuromuscular process controlling posture
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0005764 lysosome
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR015882 Beta-hexosaminidase, bacteial type, N-terminal
IPR015883 Glycoside hydrolase family 20, catalytic core
IPR017853 Glycoside hydrolase, superfamily
IPR025705 Beta-hexosaminidase
IPR029018 Chitobiase/beta-hexosaminidase domain 2-like
PFAM PF02838
PF00728
PRINTS PR00738
PIRSF PIRSF001093
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0V8R6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 504468
UniGene Bt.6065
RefSeq NP_001068632
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT026152
GenPept ABG66991

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca