Version 5.4
Bos taurus Protein: BBS4
Summary
InnateDB Protein IDBP-698334.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BBS4
Protein Name Bardet-Biedl syndrome 4 protein homolog
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000010013
InnateDB Gene IDBG-645611 (BBS4)
Protein Structure
UniProt Annotation
Function May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell projection, cilium membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250}. Note=Localizes to the pericentriolar material. Centrosomal localization requires dynein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0034452 dynactin binding
GO:0043014 alpha-tubulin binding
GO:0048487 beta-tubulin binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000281 mitotic cytokinesis
GO:0001843 neural tube closure
GO:0001895 retina homeostasis
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0006810 transport
GO:0007286 spermatid development
GO:0007608 sensory perception of smell
GO:0008104 protein localization
GO:0008152 metabolic process
GO:0010629 negative regulation of gene expression
GO:0015031 protein transport
GO:0016358 dendrite development
GO:0019216 regulation of lipid metabolic process
GO:0021756 striatum development
GO:0021766 hippocampus development
GO:0021987 cerebral cortex development
GO:0030030 cell projection organization
GO:0030534 adult behavior
GO:0032465 regulation of cytokinesis
GO:0033210 leptin-mediated signaling pathway
GO:0033365 protein localization to organelle
GO:0034454 microtubule anchoring at centrosome
GO:0035058 nonmotile primary cilium assembly
GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway
GO:0040018 positive regulation of multicellular organism growth
GO:0042384 cilium assembly
GO:0044321 response to leptin
GO:0045444 fat cell differentiation
GO:0045494 photoreceptor cell maintenance
GO:0045724 positive regulation of cilium assembly
GO:0046548 retinal rod cell development
GO:0048854 brain morphogenesis
GO:0051297 centrosome organization
GO:0051457 maintenance of protein location in nucleus
GO:0060271 cilium morphogenesis
GO:0060296 regulation of cilium beat frequency involved in ciliary motility
GO:0071539 protein localization to centrosome
Cellular Component
GO:0000242 pericentriolar material
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0016020 membrane
GO:0031513 nonmotile primary cilium
GO:0031514 motile cilium
GO:0034451 centriolar satellite
GO:0034464 BBSome
GO:0036064 ciliary basal body
GO:0042995 cell projection
GO:0060170 ciliary membrane
Protein Structure and Domains
PDB ID
InterPro IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat
PFAM PF00515
PF13174
PF13176
PF13181
PRINTS
PIRSF
SMART SM00028
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1JQ97
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 532120
UniGene Bt.7716
RefSeq NP_001069424
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116137
GenPept AAI16138

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca