InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ATP5D

Summary

InnateDB Protein

IDBP-698338.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP5D

Protein Name

ATP synthase subunit delta, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000721

InnateDB Gene

IDBG-645620 (ATP5D)

Protein Structure

UniProt Annotation

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Subcellular Localization

Mitochondrion. Mitochondrion inner membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0016887	ATPase activity
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0006754	ATP biosynthetic process
GO:0006810	transport
GO:0006811	ion transport
GO:0015986	ATP synthesis coupled proton transport
GO:0015992	proton transport

Cellular Component

GO:0005739	mitochondrion
GO:0005740	mitochondrial envelope
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0016020	membrane
GO:0045259	proton-transporting ATP synthase complex
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)

Protein Structure and Domains

PDB ID

InterPro

IPR001469 ATPase, F1 complex, delta/epsilon subunit
IPR020546 ATPase, F1 complex, delta/epsilon subunit, N-terminal
IPR020547 ATPase, F1 complex, delta/epsilon subunit, C-terminal domain

PFAM

PF02823
PF00401

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P05630

PhosphoSite