InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CAPZB

Summary

InnateDB Protein

IDBP-698461.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAPZB

Protein Name

F-actin-capping protein subunit beta

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005983

InnateDB Gene

IDBG-645719 (CAPZB)

Protein Structure

UniProt Annotation

Function

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. The isoform beta-3 may play a role in spermatogenesis. Alternatively, may play a role in later maturation steps such as capacitation and fertilization which involve changes of membrane domains. May play a role in the regulation of cell morphology and cytoskeletal organization.

Subcellular Localization

Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure tightly associated to the nucleus.

Disease Associations

Tissue Specificity

The isoform beta-3 is predominantly expressed in the testis. It is only detected in total sperm, sperm heads and the calyx fraction, but not in sperm tails or any supernatant fraction. Weaker expression also found in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0048487	beta-tubulin binding
GO:0051015	actin filament binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0022604	regulation of cell morphogenesis
GO:0030030	cell projection organization
GO:0030032	lamellipodium assembly
GO:0030036	actin cytoskeleton organization
GO:0031115	negative regulation of microtubule polymerization
GO:0031175	neuron projection development
GO:0048747	muscle fiber development
GO:0051016	barbed-end actin filament capping
GO:0051693	actin filament capping
GO:0090036	regulation of protein kinase C signaling

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0008290	F-actin capping protein complex
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0030018	Z disc
GO:0030027	lamellipodium
GO:0030863	cortical cytoskeleton
GO:0033150	cytoskeletal calyx
GO:0071203	WASH complex

Protein Structure and Domains

PDB ID

InterPro

IPR001698 F-actin-capping protein subunit beta

PFAM

PF01115

PRINTS

PR00192

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P79136

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

338052

UniGene

Bt.4730

RefSeq

NP_788821

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102613 Y10372 Z85980

GenPept

AAI02614 CAA71401 CAB06626