InnateDB Protein
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IDBP-698574.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC22A17
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Protein Name
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Solute carrier family 22 member 17
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Synonyms
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24p3R;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000036264
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InnateDB Gene
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IDBG-645822 (SLC22A17)
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Protein Structure
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Function |
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Vacuole membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Upon LCN2-binding, it is internalized. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005828
General substrate transporter
IPR016196
Major facilitator superfamily domain, general substrate transporter
IPR020846
Major facilitator superfamily domain
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PFAM |
PF00083
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3SZQ2
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
539848
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UniGene |
Bt.48982
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RefSeq |
NP_001124227
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC102752
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GenPept |
AAI02753
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