InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: H2AFY

Summary

InnateDB Protein

IDBP-698597.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2AFY

Protein Name

H2A histone family, member Y

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000021436

InnateDB Gene

IDBG-645843 (H2AFY)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000182	rDNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0010385	double-stranded methylated DNA binding
GO:0019901	protein kinase binding
GO:0030291	protein serine/threonine kinase inhibitor activity
GO:0031490	chromatin DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006334	nucleosome assembly
GO:0007549	dosage compensation
GO:0033128	negative regulation of histone phosphorylation
GO:0045814	negative regulation of gene expression, epigenetic
GO:0071169	establishment of protein localization to chromatin
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:1901837	negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
GO:1902750	negative regulation of cell cycle G2/M phase transition

Cellular Component

GO:0000786	nucleosome
GO:0000790	nuclear chromatin
GO:0000793	condensed chromosome
GO:0001740	Barr body
GO:0005634	nucleus
GO:0005694	chromosome
GO:0005730	nucleolus
GO:0035098	ESC/E(Z) complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002119 Histone H2A
IPR002589 Macro domain
IPR007125 Histone core
IPR009072 Histone-fold
IPR021171 Core histone macro-H2A

PFAM

PF01661
PF00125

PRINTS

PR00620

PIRSF

PIRSF037942

SMART

SM00414
SM00506

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q2HJ65

UniProt Splice Variant

Entrez Gene

532990

UniGene

Bt.5920

RefSeq

NP_001039805

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC113287 DAAA02020353

GenPept

AAI13288