InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RBM5

Summary

InnateDB Protein

IDBP-698613.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBM5

Protein Name

RNA-binding protein 5

Synonyms

LUCA15;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008305

InnateDB Gene

IDBG-645856 (RBM5)

Protein Structure

UniProt Annotation

Function

Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000245	spliceosomal complex assembly
GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0006915	apoptotic process
GO:0008380	RNA splicing
GO:0043065	positive regulation of apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005681	spliceosomal complex

Protein Structure and Domains

PDB ID

InterPro

IPR000467 G-patch domain
IPR000504 RNA recognition motif domain
IPR001876 Zinc finger, RanBP2-type
IPR007087 Zinc finger, C2H2

PFAM

PF01585
PF00076
PF00641
PF00096

PRINTS

PIRSF

SMART

SM00443
SM00360
SM00547

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q1RMU5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

534216

UniGene

Bt.76139

RefSeq

NP_001039839

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC114706

GenPept

AAI14707