Version 5.4
Bos taurus Protein: EPHA2
Summary
InnateDB Protein IDBP-698638.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPHA2
Protein Name EPH receptor A2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000001080
InnateDB Gene IDBG-645870 (EPHA2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001501 skeletal system development
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001649 osteoblast differentiation
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010591 regulation of lamellipodium assembly
GO:0014028 notochord formation
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021915 neural tube development
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030316 osteoclast differentiation
GO:0032863 activation of Rac GTPase activity
GO:0033598 mammary gland epithelial cell proliferation
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0036342 post-anal tail morphogenesis
GO:0043491 protein kinase B signaling
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0045765 regulation of angiogenesis
GO:0046849 bone remodeling
GO:0048013 ephrin receptor signaling pathway
GO:0048320 axial mesoderm formation
GO:0048570 notochord morphogenesis
GO:0051898 negative regulation of protein kinase B signaling
GO:0060035 notochord cell development
GO:0060326 cell chemotaxis
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0070309 lens fiber cell morphogenesis
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070848 response to growth factor
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031256 leading edge membrane
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001090 Ephrin receptor ligand binding domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001660 Sterile alpha motif domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR008979 Galactose-binding domain-like
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR015373 Interferon alpha/beta receptor, beta chain
IPR016257 Ephrin receptor type-A /type-B
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR021129 Sterile alpha motif, type 1
PFAM PF00069
PF01404
PF07714
PF00041
PF01108
PF07647
PF09294
PF00536
PRINTS PR00109
PIRSF PIRSF000666
SMART SM00615
SM00454
SM00220
SM00060
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BJ31
UniProt Splice Variant
Entrez Gene 512798
UniGene Bt.24503
RefSeq NP_001192660
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02006588
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca