InnateDB Protein
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IDBP-698647.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ABHD4
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Protein Name
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Abhydrolase domain-containing protein 4
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000022154
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InnateDB Gene
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IDBG-645893 (ABHD4)
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Protein Structure
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Function |
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity). {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000073
Alpha/beta hydrolase fold-1
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF00561
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PRINTS |
PR00111
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5EA59
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
509896
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UniGene |
Bt.28090
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RefSeq |
NP_001029540
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC114030
BT020710
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GenPept |
AAI14031
AAX08727
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