InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: APEH

Summary

InnateDB Protein

IDBP-698745.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APEH

Protein Name

Acylamino-acid-releasing enzyme

Synonyms

AARE; APH;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015388

InnateDB Gene

IDBG-645973 (APEH)

Protein Structure

UniProt Annotation

Function

This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity
GO:0008242	omega peptidase activity
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006508	proteolysis
GO:0050435	beta-amyloid metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR002925 Dienelactone hydrolase
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00326
PF01738

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P80227

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

514666

UniGene

Bt.2056

RefSeq

NP_001076900

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC123400

GenPept

AAI23401