Version 5.4
Homo sapiens Protein: CCNY
Summary
InnateDB Protein IDBP-69875.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNY
Protein Name cyclin Y
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000363836
InnateDB Gene IDBG-69871 (CCNY)
Protein Structure
UniProt Annotation
Function Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269PubMed:18060517, ECO:0000269PubMed:19524571, ECO:0000269PubMed:20059949, ECO:0000269PubMed:22184064}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:18060517, ECO:0000269PubMed:19524571, ECO:0000269PubMed:20059949, ECO:0000269PubMed:22184064}; Lipid-anchor {ECO:0000269PubMed:18060517, ECO:0000269PubMed:19524571, ECO:0000269PubMed:20059949, ECO:0000269PubMed:22184064}; Cytoplasmic side {ECO:0000269PubMed:18060517, ECO:0000269PubMed:19524571, ECO:0000269PubMed:20059949, ECO:0000269PubMed:22184064}.Isoform 3: Nucleus.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:18060517}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086 G2/M transition of mitotic cell cycle
GO:0016055 Wnt signaling pathway
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051301 cell division
GO:0060828 regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR006671 Cyclin, N-terminal
IPR012399 Cyclin Y
IPR013763 Cyclin-like
IPR013922 Cyclin PHO80-like
PFAM PF00134
PF08613
PRINTS
PIRSF PIRSF028934
SMART SM00385
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8ND76
PhosphoSite PhosphoSite-Q8ND76
TrEMBL R4GN48
UniProt Splice Variant
Entrez Gene 219771
UniGene Hs.714184
RefSeq NP_659449
HUGO HGNC:23354
OMIM 612786
CCDS CCDS7189
HPRD 10700
IMGT
EMBL AF413522 AF429969 AF465728 AF465729 AK057280 AL117336 AL121749 AL592445 AL603824 AL834355 AY504868 BC069224 BC094815 BC104773 BC104801 BC143450 BC143455 CH471072
GenPept AAH69224 AAH94815 AAI04774 AAI04802 AAI43451 AAI43456 AAL07802 AAL78998 AAL78999 AAP97301 AAS79427 BAB71409 CAD39020 CAH70072 CAH70073 CAH71567 CAH71568 CAH72501 CAH73707 CAH73709 EAW85912 EAW85913 EAW85914

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca