InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: UBE2D2

Summary

InnateDB Protein

IDBP-698792.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2D2

Protein Name

Ubiquitin-conjugating enzyme E2 D2

Synonyms

UBE2D3P;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000049292

InnateDB Gene

IDBG-646027 (UBE2D2)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3 (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 187 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	187 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016874	ligase activity
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0016567	protein ubiquitination
GO:0070936	protein K48-linked ubiquitination

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000608 Ubiquitin-conjugating enzyme, E2
IPR016135 Ubiquitin-conjugating enzyme/RWD-like

PFAM

PF00179

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q1RMX2

PhosphoSite

PhosphoSite-

TrEMBL

Q24M91

UniProt Splice Variant

Entrez Gene

541003

UniGene

Bt.36192

RefSeq

NP_001039961

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY291287 BC114654

GenPept

AAI14655 AAQ23193