InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SRN

Summary

InnateDB Protein

IDBP-698811.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRN

Protein Name

Seminal ribonuclease

Synonyms

RAC1; SRN;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000036091

InnateDB Gene

IDBG-646041 (SRN)

Protein Structure

UniProt Annotation

Function

This enzyme hydrolyzes both single- and double-stranded RNA.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Seminal plasma. Can reach 3% of the protein content of this fluid.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003824	catalytic activity
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0004522	pancreatic ribonuclease activity
GO:0016787	hydrolase activity
GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters
GO:0042802	identical protein binding

Biological Process

GO:0008152	metabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR001427 Pancreatic ribonuclease
IPR023412 Ribonuclease A-domain

PFAM

PF00074

PRINTS

PR00794

PIRSF

SMART

SM00092

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P00669

PhosphoSite

PhosphoSite-

TrEMBL

W0UV03

UniProt Splice Variant

Entrez Gene

280930

UniGene

Bt.22955

RefSeq

NP_861526

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AJ000518 HG329011 S81747 X03029 X51337

GenPept

AAB36140 CAA04155 CAA26832 CAA35716 CDG32087