InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RNASE6

Summary

InnateDB Protein

IDBP-698815.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNASE6

Protein Name

Ribonuclease K6

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011585

InnateDB Gene

IDBG-646044 (RNASE6)

Protein Structure

UniProt Annotation

Function

Pyrimidine specific nuclease with a preference for U.

Subcellular Localization

Lysosome {ECO:0000305}. Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule.

Disease Associations

Tissue Specificity

Kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0016787	hydrolase activity
GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters

Biological Process

GO:0008152	metabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005764	lysosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001427 Pancreatic ribonuclease
IPR023412 Ribonuclease A-domain

PFAM

PF00074

PRINTS

PR00794

PIRSF

SMART

SM00092

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08904

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

282341

UniGene

RefSeq

NP_777019

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF164025 BC109812 U64997

GenPept

AAC48633 AAD44349 AAI09813