Version 5.4
| Bos taurus Protein: TTC5 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-698850.2 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | TTC5 | ||||||||
| Protein Name | Tetratricopeptide repeat protein 5 | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Protein | ENSBTAP00000036097 | ||||||||
| InnateDB Gene | IDBG-646074 (TTC5) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Nucleus. Cytoplasm. Note=Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm. {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR013026
Tetratricopeptide repeat-containing domain IPR019734 Tetratricopeptide repeat |
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| PFAM |
PF13174
PF13176 PF13181 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00028
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q0P5H9 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 510757 | ||||||||
| UniGene | Bt.3106 | ||||||||
| RefSeq | NP_001068932 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | BC120007 | ||||||||
| GenPept | AAI20008 | ||||||||