InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SPRY4

Summary

InnateDB Protein

IDBP-698910.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPRY4

Protein Name

Protein sprouty homolog 4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010852

InnateDB Gene

IDBG-646136 (SPRY4)

Protein Structure

UniProt Annotation

Function

Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras (By similarity). Inhibits Ras-independent, but not Ras- dependent, activation of RAF1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007275	multicellular organismal development
GO:0009966	regulation of signal transduction
GO:0043407	negative regulation of MAP kinase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032587	ruffle membrane
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

InterPro

IPR007875 Sprouty

PFAM

PF05210

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A2VDU1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

504593

UniGene

Bt.61579

RefSeq

NP_001074981

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC133401

GenPept

AAI33402