InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: EIF2AK4

Summary

InnateDB Protein

IDBP-698984.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2AK4

Protein Name

eukaryotic translation initiation factor 2 alpha kinase 4

Synonyms

Gcn2-like;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019083

InnateDB Gene

IDBG-646199 (EIF2AK4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity

Biological Process

GO:0006446	regulation of translational initiation
GO:0006468	protein phosphorylation
GO:0009267	cellular response to starvation
GO:0017148	negative regulation of translation
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0043558	regulation of translational initiation in response to stress

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR004154 Anticodon-binding
IPR006575 RWD domain
IPR011009 Protein kinase-like domain
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
IPR016255 Serine/threonine-protein kinase, GCN2
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF03129
PF05773

PRINTS

PR00109

PIRSF

PIRSF000660

SMART

SM00220
SM00591
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References