InnateDB Protein
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IDBP-698989.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SPINK6
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Protein Name
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Serine protease inhibitor Kazal-type 6
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000044797
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InnateDB Gene
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IDBG-646207 (SPINK6)
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Protein Structure
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Function |
Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8 (By similarity). Inhibits acrosin, trypsin, and chymotrypsin. {ECO:0000250}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Seminal plasma.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0010466
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negative regulation of peptidase activity
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GO:0010951
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negative regulation of endopeptidase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR002350
Kazal domain
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PFAM |
PF00050
PF07648
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PRINTS |
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PIRSF |
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SMART |
SM00280
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TIGRFAMs |
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Modification |
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SwissProt |
P01001
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
100850600
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UniGene |
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RefSeq |
XP_002706142
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
DY218174
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GenPept |
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