Version 5.4
Bos taurus Protein: BT.46809
Summary
InnateDB Protein IDBP-699076.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.46809
Protein Name CD74 antigen
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000020261
InnateDB Gene IDBG-646288 (BT.46809)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
GO:0019955 cytokine binding
GO:0023026 MHC class II protein complex binding
GO:0035718 macrophage migration inhibitory factor binding
GO:0042289 MHC class II protein binding
GO:0042658 MHC class II protein binding, via antigen binding groove
GO:0044183 protein binding involved in protein folding
GO:0050998 nitric-oxide synthase binding
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0002792 negative regulation of peptide secretion
GO:0002830 positive regulation of type 2 immune response
GO:0002906 negative regulation of mature B cell apoptotic process
GO:0006461 protein complex assembly
GO:0006886 intracellular protein transport
GO:0006952 defense response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0016064 immunoglobulin mediated immune response
GO:0019882 antigen processing and presentation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030890 positive regulation of B cell proliferation
GO:0035691 macrophage migration inhibitory factor signaling pathway
GO:0043066 negative regulation of apoptotic process
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045581 negative regulation of T cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0048146 positive regulation of fibroblast proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051085 chaperone mediated protein folding requiring cofactor
GO:0060907 positive regulation of macrophage cytokine production
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090023 positive regulation of neutrophil chemotaxis
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
Cellular Component
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0005773 vacuole
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0035692 macrophage migration inhibitory factor receptor complex
GO:0035693 NOS2-CD74 complex
GO:0042613 MHC class II protein complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR011988 MHC class II-associated invariant chain, trimerisation
IPR015386 MHC class II-associated invariant chain/CLIP, MHC II-interacting
IPR022339 MHC class II-associated invariant chain
PFAM PF08831
PF09307
PRINTS PR01990
PIRSF PIRSF001992
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q7JFY3
UniProt Splice Variant
Entrez Gene 613384
UniGene Bt.46809
RefSeq NP_001029907
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102388 BT021489 D83959 D83960 D83961 D83962 DAAA02020627
GenPept AAI02389 AAX46336 BAA12153 BAA12154 BAA12155 BAA12156

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca