InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TYRO3

Summary

InnateDB Protein

IDBP-699095.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TYRO3

Protein Name

TYRO3 protein tyrosine kinase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002222

InnateDB Gene

IDBG-646302 (TYRO3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001779	natural killer cell differentiation
GO:0006468	protein phosphorylation
GO:0007283	spermatogenesis
GO:0016310	phosphorylation
GO:0021885	forebrain cell migration
GO:0030168	platelet activation
GO:0032940	secretion by cell
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042698	ovulation cycle
GO:0043277	apoptotic cell clearance
GO:0043491	protein kinase B signaling
GO:0043524	negative regulation of neuron apoptotic process
GO:0045824	negative regulation of innate immune response
GO:0046777	protein autophosphorylation
GO:0050728	negative regulation of inflammatory response
GO:0051250	negative regulation of lymphocyte activation
GO:0060068	vagina development
GO:0070050	neuron cellular homeostasis
GO:0070527	platelet aggregation

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM