InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ANXA6

Summary

InnateDB Protein

IDBP-699115.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANXA6

Protein Name

Annexin A6

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019719

InnateDB Gene

IDBG-646320 (ANXA6)

Protein Structure

UniProt Annotation

Function

May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.

Subcellular Localization

Cytoplasm {ECO:0000250}. Melanosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005262	calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0005544	calcium-dependent phospholipid binding
GO:0008201	heparin binding
GO:0008289	lipid binding
GO:0015276	ligand-gated ion channel activity
GO:0015485	cholesterol binding
GO:0019899	enzyme binding
GO:0035374	chondroitin sulfate binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0048306	calcium-dependent protein binding
GO:0051015	actin filament binding

Biological Process

GO:0003418	growth plate cartilage chondrocyte differentiation
GO:0006816	calcium ion transport
GO:0006937	regulation of muscle contraction
GO:0031214	biomineral tissue development
GO:0034220	ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0070509	calcium ion import

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030061	mitochondrial crista
GO:0031902	late endosome membrane
GO:0031988	membrane-bounded vesicle
GO:0042470	melanosome
GO:0042584	chromaffin granule membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001464 Annexin
IPR002391 Annexin, type IV
IPR002393 Annexin, type VI
IPR018502 Annexin repeat

PFAM

PF00191

PRINTS

PR00196
PR00200
PR00202

PIRSF

SMART

SM00335

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P79134

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

327685

UniGene

Bt.5267

RefSeq

NP_001096694

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC151391 U87539

GenPept

AAB47570 AAI51392