InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RAF1

Summary

InnateDB Protein

IDBP-699184.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAF1

Protein Name

RAF proto-oncogene serine/threonine-protein kinase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005930

InnateDB Gene

IDBG-646381 (RAF1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0017016	Ras GTPase binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0030154	cell differentiation
GO:0031333	negative regulation of protein complex assembly
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0035019	somatic stem cell maintenance
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0045104	intermediate filament cytoskeleton organization
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0071550	death-inducing signaling complex assembly
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0031143	pseudopodium

Protein Structure and Domains

PDB ID

InterPro

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR003116 Raf-like Ras-binding
IPR020454 Diacylglycerol/phorbol-ester binding
IPR029071 Ubiquitin-related domain

PFAM

PF00130
PF02196

PRINTS

PR00008

PIRSF

SMART

SM00109
SM00455

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt