Version 5.4
Bos taurus Protein: ITK
Summary
InnateDB Protein IDBP-699186.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITK
Protein Name tyrosine-protein kinase ITK/TSK
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000034966
InnateDB Gene IDBG-646384 (ITK)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001816 cytokine production
GO:0001865 NK T cell differentiation
GO:0002250 adaptive immune response
GO:0006468 protein phosphorylation
GO:0007202 activation of phospholipase C activity
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0032609 interferon-gamma production
GO:0032633 interleukin-4 production
GO:0035556 intracellular signal transduction
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005911 cell-cell junction
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR001562 Zinc finger, Btk motif
IPR001849 Pleckstrin homology domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF00017
PF14633
PF07714
PF00018
PF14604
PF00779
PF00169
PF07653
PRINTS PR00401
PR00109
PR00452
PR00402
PIRSF
SMART SM00252
SM00326
SM00107
SM00233
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A7Z039
UniProt Splice Variant
Entrez Gene 522311
UniGene Bt.58287
RefSeq NP_001098858
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC153237 DAAA02020788 DAAA02020789
GenPept AAI53238

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca