Bos taurus Protein: GABRA1 | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||
InnateDB Protein | IDBP-699245.2 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | GABRA1 | ||||||||||||||
Protein Name | Gamma-aminobutyric acid receptor subunit alpha-1 | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Protein | ENSBTAP00000009483 | ||||||||||||||
InnateDB Gene | IDBG-646440 (GABRA1) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel. {ECO:0000269PubMed:3037384}. | ||||||||||||||
Subcellular Localization | Cell junction, synapse, postsynaptic cell membrane {ECO:0000269PubMed:3037384}; Multi-pass membrane protein {ECO:0000269PubMed:3037384}. Cell membrane {ECO:0000269PubMed:3037384}; Multi-pass membrane protein {ECO:0000269PubMed:3037384}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | Cerebellar granule cells, Purkinje cells and stellate/basket cells. | ||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
|
||||||||||||||
Gene Ontology | |||||||||||||||
Molecular Function |
|
||||||||||||||
Biological Process |
|
||||||||||||||
Cellular Component |
|
||||||||||||||
Protein Structure and Domains | |||||||||||||||
PDB ID | |||||||||||||||
InterPro |
IPR001390
Gamma-aminobutyric-acid A receptor, alpha subunit IPR005431 Gamma-aminobutyric-acid A receptor, alpha 1 subunit IPR005437 Gamma-aminobutyric-acid A receptor, gamma subunit IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha IPR006029 Neurotransmitter-gated ion-channel transmembrane domain IPR006201 Neurotransmitter-gated ion-channel IPR006202 Neurotransmitter-gated ion-channel ligand-binding |
||||||||||||||
PFAM |
PF02932
PF02931 |
||||||||||||||
PRINTS |
PR01079
PR01614 PR01620 PR00253 PR00252 |
||||||||||||||
PIRSF | |||||||||||||||
SMART | |||||||||||||||
TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | P08219 | ||||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 780973 | ||||||||||||||
UniGene | Bt.87630 | ||||||||||||||
RefSeq | NP_001178048 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | BC114156 X05717 | ||||||||||||||
GenPept | AAI14157 CAA29189 | ||||||||||||||