InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ATL1

Summary

InnateDB Protein

IDBP-699261.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATL1

Protein Name

Atlastin-1

Synonyms

atlastin; SPG3A;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019032

InnateDB Gene

IDBG-646455 (ATL1)

Protein Structure

UniProt Annotation

Function

GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0016787	hydrolase activity
GO:0042802	identical protein binding

Biological Process

GO:0007029	endoplasmic reticulum organization
GO:0007409	axonogenesis
GO:0051260	protein homooligomerization

Cellular Component

GO:0000137	Golgi cis cisterna
GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

InterPro

IPR003191 Guanylate-binding protein, C-terminal
IPR015894 Guanylate-binding protein, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02841
PF02263

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q58D72

PhosphoSite