Version 5.4
Bos taurus Protein: DHFR
Summary
InnateDB Protein IDBP-699291.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHFR
Protein Name dihydrofolate reductase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000010103
InnateDB Gene IDBG-646481 (DHFR)
Protein Structure
UniProt Annotation
Function Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0004146 dihydrofolate reductase activity
GO:0008144 drug binding
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0006545 glycine biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0009165 nucleotide biosynthetic process
GO:0031427 response to methotrexate
GO:0046653 tetrahydrofolate metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001796 Dihydrofolate reductase domain
IPR012259 Dihydrofolate reductase
IPR024072 Dihydrofolate reductase-like domain
PFAM PF00186
PRINTS PR00070
PIRSF PIRSF000194
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P00376
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 508809
UniGene Bt.90155
RefSeq NP_001071351
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114162
GenPept AAI14163

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca