InnateDB Protein
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IDBP-699429.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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POLR2M
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Protein Name
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Protein GRINL1A
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000056555
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InnateDB Gene
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IDBG-646609 (POLR2M)
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Protein Structure
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Function |
Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in Mediator complex-dependent regulation of transcription activation. Acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000269PubMed:16769904}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
15 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003899
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DNA-directed RNA polymerase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q17QE3
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
100125877
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UniGene |
Bt.45968
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RefSeq |
XP_005211707
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC118412
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GenPept |
AAI18413
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