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InnateDB Protein
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IDBP-699430.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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POLR2M
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Protein Name
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Protein GRINL1A
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000002841
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InnateDB Gene
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IDBG-646609 (POLR2M)
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Protein Structure
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| Function |
Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in Mediator complex-dependent regulation of transcription activation. Acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000269PubMed:16769904}.
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| Subcellular Localization |
Nucleus {ECO:0000305}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
15 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0003899
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DNA-directed RNA polymerase activity
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q17QE3
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
100125877
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| UniGene |
Bt.45968
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| RefSeq |
NP_001098947
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| HUGO |
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
BC118412
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| GenPept |
AAI18413
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Version 5.4