Version 5.4
Bos taurus Protein: NEDD4
Summary
InnateDB Protein IDBP-699452.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEDD4
Protein Name neural precursor cell expressed, developmentally down-regulated 4
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000018331
InnateDB Gene IDBG-646632 (NEDD4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 218 interaction(s) predicted by orthology.
Predicted by orthology
Total 218 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0019871 sodium channel inhibitor activity
GO:0019904 protein domain specific binding
GO:0031698 beta-2 adrenergic receptor binding
GO:0043130 ubiquitin binding
GO:0050815 phosphoserine binding
GO:0050816 phosphothreonine binding
GO:0070063 RNA polymerase binding
GO:0070064 proline-rich region binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002250 adaptive immune response
GO:0003151 outflow tract morphogenesis
GO:0003197 endocardial cushion development
GO:0006513 protein monoubiquitination
GO:0006622 protein targeting to lysosome
GO:0007041 lysosomal transport
GO:0007528 neuromuscular junction development
GO:0010766 negative regulation of sodium ion transport
GO:0010768 negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016567 protein ubiquitination
GO:0019089 transmission of virus
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031175 neuron projection development
GO:0031623 receptor internalization
GO:0032801 receptor catabolic process
GO:0034644 cellular response to UV
GO:0034765 regulation of ion transmembrane transport
GO:0042110 T cell activation
GO:0042391 regulation of membrane potential
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042921 glucocorticoid receptor signaling pathway
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0044111 development involved in symbiotic interaction
GO:0045732 positive regulation of protein catabolic process
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0048514 blood vessel morphogenesis
GO:0048814 regulation of dendrite morphogenesis
GO:0050807 regulation of synapse organization
GO:0050847 progesterone receptor signaling pathway
GO:1901016 regulation of potassium ion transmembrane transporter activity
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0000785 chromatin
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR000569 HECT
IPR001202 WW domain
PFAM PF00168
PF00632
PF00397
PRINTS PR00360
PIRSF
SMART SM00239
SM00119
SM00456
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MJ10
UniProt Splice Variant
Entrez Gene
UniGene Bt.79514
RefSeq
HUGO HGNC:7727
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02028881
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca