Version 5.4
| Bos taurus Protein: SOCS4 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Protein | IDBP-699543.2 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | SOCS4 | ||||||||||||
| Protein Name | Suppressor of cytokine signaling 4 | ||||||||||||
| Synonyms | SOCS6; | ||||||||||||
| Species | Bos taurus | ||||||||||||
| Ensembl Protein | ENSBTAP00000029320 | ||||||||||||
| InnateDB Gene | IDBG-646714 (SOCS4) | ||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity). {ECO:0000250}. | ||||||||||||
| Subcellular Localization | |||||||||||||
| Disease Associations | |||||||||||||
| Tissue Specificity | |||||||||||||
| Comments | |||||||||||||
| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||
| PDB ID | |||||||||||||
| InterPro |
IPR000980
SH2 domain IPR001496 SOCS protein, C-terminal IPR022252 SOCS4/SOCS5 domain |
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| PFAM |
PF00017
PF14633 PF07525 PF12610 |
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| PRINTS |
PR00401
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| PIRSF | |||||||||||||
| SMART |
SM00252
SM00253 SM00969 |
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| TIGRFAMs | |||||||||||||
| Post-translational Modifications | |||||||||||||
| Modification | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | Q0VC91 | ||||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 540412 | ||||||||||||
| UniGene | Bt.22739 | ||||||||||||
| RefSeq | NP_001069686 | ||||||||||||
| HUGO | |||||||||||||
| OMIM | |||||||||||||
| CCDS | |||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | BC120292 | ||||||||||||
| GenPept | AAI20293 | ||||||||||||