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InnateDB Protein
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IDBP-699584.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TRMT5
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Protein Name
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tRNA (guanine-N(1)-)-methyltransferase
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000015658
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InnateDB Gene
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IDBG-646753 (TRMT5)
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Protein Structure
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| Function |
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. {ECO:0000255HAMAP- Rule:MF_03152}.
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| Subcellular Localization |
Mitochondrion matrix {ECO:0000255HAMAP- Rule:MF_03152}. Nucleus {ECO:0000255HAMAP-Rule:MF_03152}. Cytoplasm {ECO:0000255HAMAP-Rule:MF_03152}. Note=Predominantly in the mitochondria and in the nucleus. {ECO:0000255HAMAP- Rule:MF_03152}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
| Accession |
GO Term |
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GO:0008168
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methyltransferase activity
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GO:0009019
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tRNA (guanine-N1-)-methyltransferase activity
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GO:0016740
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transferase activity
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GO:0052906
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tRNA (guanine(37)-N(1))-methyltransferase activity
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR003402
tRNA transferase Trm5/Tyw2
IPR029063
S-adenosyl-L-methionine-dependent methyltransferase-like
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| PFAM |
PF02475
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q3MHN8
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
528221
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| UniGene |
Bt.17870
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| RefSeq |
NP_001029737
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| HUGO |
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
BC105167
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| GenPept |
AAI05168
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Version 5.4