Version 5.4
Bos taurus Protein: TGFB3
Summary
InnateDB Protein IDBP-699722.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGFB3
Protein Name transforming growth factor beta-3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000015925
InnateDB Gene IDBG-646881 (TGFB3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005160 transforming growth factor beta receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0034713 type I transforming growth factor beta receptor binding
GO:0042802 identical protein binding
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007435 salivary gland morphogenesis
GO:0008156 negative regulation of DNA replication
GO:0008285 negative regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936 negative regulation of macrophage cytokine production
GO:0016049 cell growth
GO:0022601 menstrual cycle phase
GO:0030501 positive regulation of bone mineralization
GO:0030879 mammary gland development
GO:0032570 response to progesterone
GO:0032967 positive regulation of collagen biosynthetic process
GO:0040007 growth
GO:0043065 positive regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043932 ossification involved in bone remodeling
GO:0045216 cell-cell junction organization
GO:0045740 positive regulation of DNA replication
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048286 lung alveolus development
GO:0050714 positive regulation of protein secretion
GO:0051491 positive regulation of filopodium assembly
GO:0060021 palate development
GO:0060325 face morphogenesis
GO:0060391 positive regulation of SMAD protein import into nucleus
GO:0070483 detection of hypoxia
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID
InterPro IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR015618 Transforming growth factor beta 3
IPR016319 Transforming growth factor-beta
IPR029034 Cystine-knot cytokine
PFAM PF00688
PF00019
PRINTS PR01426
PR01423
PIRSF PIRSF001787
SMART SM00204
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A6QP91
UniProt Splice Variant
Entrez Gene 538957
UniGene Bt.54513
RefSeq NP_001094653
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149207 DAAA02029647
GenPept AAI49208

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca