InnateDB Protein
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IDBP-69977.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ALKBH8
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Protein Name
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alkB, alkylation repair homolog 8 (E. coli)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000260318
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InnateDB Gene
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IDBG-69973 (ALKBH8)
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Protein Structure
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Function |
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis. {ECO:0000269PubMed:19293182, ECO:0000269PubMed:20308323}.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
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Disease Associations |
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Tissue Specificity |
Widely expressed, with highest expression in spleen, followed by pancreas and lung. {ECO:0000269PubMed:17979886}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0003676
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nucleic acid binding
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GO:0003723
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RNA binding
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GO:0005515
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protein binding
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GO:0008168
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methyltransferase activity
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GO:0016300
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tRNA (uracil) methyltransferase activity
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GO:0016706
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oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
IPR015095
Alkylated DNA repair protein AlkB, homologue 8, N-terminal
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PFAM |
PF00076
PF09004
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q96BT7
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PhosphoSite |
PhosphoSite-Q96BT7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
91801
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UniGene |
Hs.606625
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RefSeq |
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HUGO |
HGNC:25189
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OMIM |
613306
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CCDS |
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HPRD |
14287
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IMGT |
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EMBL |
AB218768
AK095523
AK293603
AK304413
AP001823
BC015183
CH471065
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GenPept |
AAH15183
BAC04566
BAG16270
BAG57067
BAG65244
EAW67089
EAW67090
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