InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CALM

Summary

InnateDB Protein

IDBP-699779.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CALM

Protein Name

Calmodulin

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000036057

InnateDB Gene

IDBG-646928 (CALM)

Protein Structure

UniProt Annotation

Function

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0031432	titin binding
GO:0031996	thioesterase binding
GO:0031997	N-terminal myristoylation domain binding
GO:0043274	phospholipase binding
GO:0044325	ion channel binding
GO:0046872	metal ion binding
GO:0072542	protein phosphatase activator activity

Biological Process

GO:0002027	regulation of heart rate
GO:0005513	detection of calcium ion
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0021762	substantia nigra development
GO:0030801	positive regulation of cyclic nucleotide metabolic process
GO:0032465	regulation of cytokinesis
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0035307	positive regulation of protein dephosphorylation
GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051592	response to calcium ion
GO:0055117	regulation of cardiac muscle contraction
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005876	spindle microtubule
GO:0030017	sarcomere
GO:0034704	calcium channel complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002048 EF-hand domain
IPR014837 EF-hand, Ca insensitive

PFAM

PF00036
PF13202
PF13405
PF08726

PRINTS

PIRSF

SMART

SM00054

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P62157

PhosphoSite

PhosphoSite-P62157

TrEMBL

UniProt Splice Variant

Entrez Gene

617095

UniGene

Bt.61778

RefSeq

NP_001229501

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB099053 BC105380 BC120080 BC123890

GenPept

AAI05381 AAI20081 AAI23891 BAC56543