Version 5.4
Bos taurus Protein: NOG
Summary
InnateDB Protein IDBP-699917.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOG
Protein Name noggin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000056514
InnateDB Gene IDBG-647068 (NOG)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019955 cytokine binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001655 urogenital system development
GO:0001657 ureteric bud development
GO:0001701 in utero embryonic development
GO:0001706 endoderm formation
GO:0001707 mesoderm formation
GO:0001837 epithelial to mesenchymal transition
GO:0001839 neural plate morphogenesis
GO:0001843 neural tube closure
GO:0007389 pattern specification process
GO:0007411 axon guidance
GO:0007417 central nervous system development
GO:0007420 brain development
GO:0008045 motor neuron axon guidance
GO:0009953 dorsal/ventral pattern formation
GO:0010629 negative regulation of gene expression
GO:0021510 spinal cord development
GO:0021533 cell differentiation in hindbrain
GO:0021915 neural tube development
GO:0021983 pituitary gland development
GO:0030336 negative regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030510 regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0035019 somatic stem cell maintenance
GO:0042060 wound healing
GO:0042474 middle ear morphogenesis
GO:0042733 embryonic digit morphogenesis
GO:0045596 negative regulation of cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048318 axial mesoderm development
GO:0048570 notochord morphogenesis
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048712 negative regulation of astrocyte differentiation
GO:0048762 mesenchymal cell differentiation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060173 limb development
GO:0060272 embryonic skeletal joint morphogenesis
GO:0060302 negative regulation of cytokine activity
GO:0060325 face morphogenesis
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060425 lung morphogenesis
GO:0060513 prostatic bud formation
GO:0060676 ureteric bud formation
GO:0060825 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
GO:0061037 negative regulation of cartilage development
GO:0061053 somite development
GO:0071773 cellular response to BMP stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090193 positive regulation of glomerulus development
GO:2000313 regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR008717 Noggin
IPR029034 Cystine-knot cytokine
PFAM PF05806
PRINTS
PIRSF PIRSF008129
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3N3L0
UniProt Splice Variant
Entrez Gene 538769
UniGene
RefSeq XP_002695600
HUGO HGNC:7866
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02048254
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca