InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HIST1H3J

Summary

InnateDB Protein

IDBP-699956.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIST1H3J

Protein Name

Histone H3.1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000052244

InnateDB Gene

IDBG-647108 (HIST1H3J)

Protein Structure

UniProt Annotation

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006334	nucleosome assembly
GO:0006335	DNA replication-dependent nucleosome assembly
GO:0060968	regulation of gene silencing

Cellular Component

GO:0000228	nuclear chromosome
GO:0000786	nucleosome
GO:0005634	nucleus
GO:0005694	chromosome
GO:0016020	membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000164 Histone H3/CENP-A
IPR007125 Histone core
IPR009072 Histone-fold

PFAM

PF00125

PRINTS

PR00622

PIRSF

SMART

SM00428

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P68432

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

788250

UniGene

RefSeq

XP_002688551

HUGO

HGNC:4767

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept