InnateDB Protein
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IDBP-700011.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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THAP11
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Protein Name
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THAP domain-containing protein 11
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000008406
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InnateDB Gene
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IDBG-647162 (THAP11)
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Protein Structure
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Function |
Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
16 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006612
Zinc finger, C2CH-type
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PFAM |
PF05485
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PRINTS |
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PIRSF |
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SMART |
SM00692
SM00980
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TIGRFAMs |
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Modification |
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SwissProt |
A5PKF5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
539845
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UniGene |
Bt.6648
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RefSeq |
NP_001098464
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC142469
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GenPept |
AAI42470
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