InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP13A4

Summary

InnateDB Protein

IDBP-70002.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP13A4

Protein Name

ATPase type 13A4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000295548

InnateDB Gene

IDBG-69998 (ATP13A4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Note=A chromosomal aberration involving ATP13A4 is found in 2 patients with specific language impairment (SLI) disorders. Paracentric inversion inv(3)(q25;q29). The inversion produces a disruption of the protein.

Tissue Specificity

Expressed in heart, placenta, liver, skeletal muscles, and pancreas. Lower levels of expression are also detected in brain, lung and kidney. Weakly expressed in the adult brain. Expression in fetal brain is higher than in adult brain, with levels similar to several other fetal tissues including spleen and skeletal muscle. In adult brain expressed at low levels in all tissues examined, including the temporal lobe and putamen. {ECO:0000269PubMed:15925480}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006812	cation transport

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR006544 Cation-transporting P-type ATPase, subfamily V
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain

PFAM

PF00690
PF12409
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

SM00831

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt