InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ADRA2B

Summary

InnateDB Protein

IDBP-700028.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRA2B

Protein Name

Alpha-2B adrenergic receptor

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000012514

InnateDB Gene

IDBG-647179 (ADRA2B)

Protein Structure

UniProt Annotation

Function

Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004935	adrenergic receptor activity
GO:0004938	alpha2-adrenergic receptor activity
GO:0005515	protein binding
GO:0051379	epinephrine binding

Biological Process

GO:0000165	MAPK cascade
GO:0001525	angiogenesis
GO:0006940	regulation of smooth muscle contraction
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0019229	regulation of vasoconstriction
GO:0030168	platelet activation
GO:0032148	activation of protein kinase B activity
GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0045666	positive regulation of neuron differentiation
GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000207 Alpha 2B adrenoceptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00559
PR00237
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O77700