InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FOXL2

Summary

InnateDB Protein

IDBP-700166.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXL2

Protein Name

Forkhead box protein L2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000041814

InnateDB Gene

IDBG-647332 (FOXL2)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination (By similarity). Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells (By similarity). Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Activates SIRT1 transcription under cellular stress conditions (By similarity). Activates transcription of OSR2 (By similarity). Is a regulator of CYP19 expression (By similarity). Is a transcriptional repressor of STAR (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00089}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0030331	estrogen receptor binding
GO:0031624	ubiquitin conjugating enzyme binding
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001541	ovarian follicle development
GO:0002074	extraocular skeletal muscle development
GO:0006309	apoptotic DNA fragmentation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0019101	female somatic sex determination
GO:0030154	cell differentiation
GO:0042703	menstruation
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048048	embryonic eye morphogenesis
GO:0060014	granulosa cell differentiation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001766 Transcription factor, fork head

PFAM

PF00250

PRINTS

PR00053

PIRSF

SMART

SM00339

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6VFT7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

281770

UniGene

Bt.13033

RefSeq

NP_001026920

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY116404 AY340970

GenPept

AAM77968 AAQ91844