InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ALDH1B1

Summary

InnateDB Protein

IDBP-700293.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDH1B1

Protein Name

Aldehyde dehydrogenase X, mitochondrial

Synonyms

ALDH5; ALDHX;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000027172

InnateDB Gene

IDBG-647471 (ALDH1B1)

Protein Structure

UniProt Annotation

Function

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. In the cornea, this enzyme may help in the absorption of the damaging UV-B, as well as in the detoxification of the UV-induced peroxidic aldehydes.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004029	aldehyde dehydrogenase (NAD) activity
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Biological Process

GO:0006068	ethanol catabolic process
GO:0008152	metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR015590 Aldehyde dehydrogenase domain
IPR016161 Aldehyde/histidinol dehydrogenase

PFAM

PF00171

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P52476

PhosphoSite

PhosphoSite-

TrEMBL

G5E5P4

UniProt Splice Variant

Entrez Gene

281618

UniGene

Bt.13145

RefSeq

XP_005199268

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AAFC03050684 DAAA02023239 S61045

GenPept

AAB26659