InnateDB Protein
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IDBP-700592.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATP5E
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Protein Name
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ATP synthase subunit epsilon, mitochondrial
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000035213
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InnateDB Gene
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IDBG-647802 (ATP5E)
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Protein Structure
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Function |
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
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Subcellular Localization |
Mitochondrion. Mitochondrion inner membrane.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0046933
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proton-transporting ATP synthase activity, rotational mechanism
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GO:0046961
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proton-transporting ATPase activity, rotational mechanism
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Biological Process |
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Cellular Component |
GO:0000275
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mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
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GO:0005739
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mitochondrion
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GO:0005743
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mitochondrial inner membrane
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GO:0005753
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mitochondrial proton-transporting ATP synthase complex
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GO:0016020
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membrane
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GO:0045261
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proton-transporting ATP synthase complex, catalytic core F(1)
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PDB ID |
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InterPro |
IPR006721
ATPase, F1 complex, epsilon subunit, mitochondrial
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PFAM |
PF04627
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P05632
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
782270
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UniGene |
Bt.5510
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RefSeq |
XP_001250629
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC108146
X16978
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GenPept |
AAI08147
CAA34849
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