Bos taurus Protein: DRD1
Summary
InnateDB Protein IDBP-700615.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DRD1
Protein Name D(1A) dopamine receptor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000054107
InnateDB Gene IDBG-647825 (DRD1)
Protein Structure
UniProt Annotation
Function Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001588 dopamine receptor activity, coupled via Gs
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004952 dopamine receptor activity
GO:0005515 protein binding
GO:0035240 dopamine binding
Biological Process
GO:0001659 temperature homeostasis
GO:0001661 conditioned taste aversion
GO:0001662 behavioral fear response
GO:0001963 synaptic transmission, dopaminergic
GO:0001975 response to amphetamine
GO:0006606 protein import into nucleus
GO:0006936 muscle contraction
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007612 learning
GO:0007613 memory
GO:0007617 mating behavior
GO:0007625 grooming behavior
GO:0007626 locomotory behavior
GO:0007628 adult walking behavior
GO:0007631 feeding behavior
GO:0008306 associative learning
GO:0008542 visual learning
GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0014002 astrocyte development
GO:0015872 dopamine transport
GO:0019226 transmission of nerve impulse
GO:0019228 neuronal action potential
GO:0021542 dentate gyrus development
GO:0021756 striatum development
GO:0021766 hippocampus development
GO:0021853 cerebral cortex GABAergic interneuron migration
GO:0030335 positive regulation of cell migration
GO:0030432 peristalsis
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0035106 operant conditioning
GO:0042053 regulation of dopamine metabolic process
GO:0042220 response to cocaine
GO:0042311 vasodilation
GO:0042493 response to drug
GO:0042711 maternal behavior
GO:0046323 glucose import
GO:0046959 habituation
GO:0046960 sensitization
GO:0048148 behavioral response to cocaine
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0060291 long-term synaptic potentiation
GO:0060292 long term synaptic depression
GO:0071870 cellular response to catecholamine stimulus
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000929 Dopamine receptor family
IPR001413 Dopamine D1 receptor
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)
PFAM PF00001
PF10320
PF10328
PRINTS PR00237
PR00242
PR00565
PR01103
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q95136
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281125
UniGene Bt.9029
RefSeq NP_776467
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF381032 BC134576 U73042
GenPept AAB17281 AAI34577 AAL37945