Version 5.4
Bos taurus Protein: GPR68
Summary
InnateDB Protein IDBP-700676.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR68
Protein Name Ovarian cancer G-protein coupled receptor 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008858
InnateDB Gene IDBG-647890 (GPR68)
Protein Structure
UniProt Annotation
Function Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (By similarity). Function also as a metastasis suppressor gene in prostate cancer (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032024 positive regulation of insulin secretion
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045656 negative regulation of monocyte differentiation
GO:0071467 cellular response to pH
GO:2001206 positive regulation of osteoclast development
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR005389 OGR1 sphingosylphosphorylcholine receptor
IPR005464 Psychosine receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)
PFAM PF00001
PF10320
PF10328
PRINTS PR00237
PR01564
PR01649
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O46685
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281799
UniGene Bt.4597
RefSeq NP_776754
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL U88366 U88367
GenPept AAC05611 AAC05612

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca