Version 5.4
Bos taurus Protein: EID2
Summary
InnateDB Protein IDBP-700863.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EID2
Protein Name EP300-interacting inhibitor of differentiation 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000048116
InnateDB Gene IDBG-648097 (EID2)
Protein Structure
UniProt Annotation
Function Interacts with EP300 and acts as a repressor of MYOD- dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex (By similarity). {ECO:0000250UniProtKB:Q8N6I1}.
Subcellular Localization Nucleus {ECO:0000250UniProtKB:Q8N6I1}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0007517 muscle organ development
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q17QW4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 615269
UniGene Bt.46414
RefSeq NP_001071517
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118143
GenPept AAI18144

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca