Version 5.4
Bos taurus Protein: BLOC1S3
Summary
InnateDB Protein IDBP-700867.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BLOC1S3
Protein Name Biogenesis of lysosome-related organelles complex 1 subunit 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000009293
InnateDB Gene IDBG-648101 (BLOC1S3)
Protein Structure
UniProt Annotation
Function Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001654 eye development
GO:0007596 blood coagulation
GO:0008089 anterograde axon cargo transport
GO:0030168 platelet activation
GO:0031175 neuron projection development
GO:0032402 melanosome transport
GO:0032438 melanosome organization
GO:0032816 positive regulation of natural killer cell activation
GO:0033299 secretion of lysosomal enzymes
GO:0035646 endosome to melanosome transport
GO:0042493 response to drug
GO:0043473 pigmentation
GO:0048066 developmental pigmentation
GO:0048490 anterograde synaptic vesicle transport
GO:0060155 platelet dense granule organization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030133 transport vesicle
GO:0031083 BLOC-1 complex
Protein Structure and Domains
PDB ID
InterPro IPR017245 BLOC-1 complex, subunit 3
PFAM
PRINTS
PIRSF PIRSF037630
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A5PJP1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 538539
UniGene Bt.62289
RefSeq XP_003583487
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142188
GenPept AAI42189

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca